Cellular adhesion molecules in rat adjuvant arthritis

Cellular Adhesion and Adhesion Molecules

In recent years, cell adhesion and cell adhesion molecules have been shown to be important for many normal biological processes, including embryonic cell migration, immune system functions and wound healing. It has also been shown that they contribute to the pathogenesis of a large number of common human disorders, such as rheumatoid arthritis and tumor cell metastasis in cancer. In this review...

Pentoxifylline Decreases Serum Level of Adhesion Molecules in Atherosclerosis Patients

Background: Inflammation is involved in development, progression, and complications of atherosclerotic disease. Clinical studies have indicated that the level of monocyte chemoattractant protein 1 (MCP-1), IL-18, and adhesion molecules correlates with the severity of atherosclerosis and can predict future cardiovascular events. Experimental studies have shown pentoxifylline (PTX) reduces these ...

Oxidative Stress and Cellular Adhesion Molecules in Acute Pancreatitis

Collagen metabolism in adjuvant-induced arthritis in the rat.

The adjuvant arthritis of the rat is a systemic disease afflicting the musculoskeletal structures, accompanied by a number of visceral manifestations (Pearson, 1956; Pearson and Wood, 1959). It has been receiving considerable attention in studies of the factors that may influence the development and course of the rheumatic diseases in man (Leader, Gorham, and Wagner, 1967). This experimental ar...

The mast cell in early rat adjuvant arthritis.

Adjuvant arthritis is a prominent feature of the disease which follows 9 to 14 days after normal rats are given a single intradermal injection of a myco-bacterial adjuvant mixture. Most accounts of the microscopic changes seen in the limb joints have described the late changes, after the disease is and Waksman (1964a) analysed the initial lesions but disagreed on the characteristics of the cell...